The accident occurred at around 5:00 pm (1700 GMT) at a bridge crossing the Bagoe river, it added.
“A bus… that was leaving Kenieba commune for Burkina Faso tipped off a bridge. The likely cause is the driver losing control of the vehicle,” the ministry said in a statement, reports AFP.
Automobile accidents are frequent in Mali, where many roads and highways as well as vehicles are in poor condition.