With a few handshakes, a brief photoshoot and a wave, NASA astronaut Frank Rubio bid farewell to the American-football-field-sized collection of modules and solar panels that had been his home for 371 days. His departure from the International Space Station (ISS) and return to Earth in October 2023 marked the end of the longest single spaceflight by an American to date.

His time in orbit – which surpassed the previous US record of 355 consecutive days – was extended in March 2023 after the spacecraft he and his crewmates had been due to fly home in developed a coolant leak. The extra months in space allowed Rubio to clock up a total of 5,963 orbits around the Earth, travelling 157.4 million miles (253.3 million km).

Even so, he was still around two months short of the record for the longest ever spaceflight by a human – Russian cosmonaut Valeri Polyakov spent 437 days onboard the Mir Space Station in the mid 1990s.

The pair departed the ISS in the Soyuz MS-25 spacecraft along with US astronaut Tracy Dyson, who had spent six months onboard.

With a huge grin on his face, Kononenko gave a double thumbs up as he was helped from the re-entry capsule after it bumped back to Earth in a cloud of dust near the remote town of Dzhezkazgan on the Kazakhstan Steppe. He now also holds the record for the longest cumulative time in space – a total of 1,111 days in orbit.

Kononenko and Chub travelled more than 158 million miles during their 5,984 orbits of the Earth in the latest mission to the ISS. But spending so much time in the low gravity environment of the space station took a toll on their bodies, so they had to be lifted out of the capsule by the recovery teams.

It is information that will prove vital as humans set their sights on sending crews on missions to explore deeper into the Solar System. A return journey to Mars, for example, is expected to take around 1,100 days (just over three years) under current plans. The spacecraft they will travel in will be far smaller than the ISS, meaning smaller lightweight exercise devices will be needed.

But problems keeping fit aside, just what does spaceflight do to the human body?

Muscles and bones

Similarly, because astronauts are not putting their skeletons through as much mechanical strain as they do when subject to Earth’s gravity, their bones also start to demineralise and lose strength.

Astronauts can lose 1-2% of their bone mass every month they spend in space and up to 10% over a six-month period (on Earth, older men and women lose bone mass at a rate of 0.5%-1% every year). This can increase their risk of suffering fractures and increase the amount of time it takes to heal. It can take up to four years for their bone mass to return to normal after returning to Earth.

To combat this, astronauts undertake 2.5 hours a day of exercise and intense training while in orbit on the ISS. This includes a series of squats, deadlifts, rows and bench presses using a resistive exercise device installed in the ISS’s “gym”, alongside regular bouts tethered to a treadmill and on an exercise bike. They also take diet supplements to help keep their bones as healthy as possible.

A recent study, however, highlighted that even this exercise regime was not enough to prevent losses in muscle function and size. It recommended testing whether higher loads in resistance exercises and high intensity interval training might help to counteract this muscle loss.

“I think my spine has extended just enough that I’m kind of wedged into my seat liner, so I shouldn’t move much at all,” he said.

Weight loss

Although weight means very little while in orbit – the microgravity environment means anything not tethered down can float around the ISS habitat freely, including human bodies – maintaining a healthy weight is a challenge while in orbit.

Although NASA tries to ensure its astronauts have a diverse range of nutritious foods, including most recently a few salad leaves grown on board the space station, it can still affect an astronaut’s body.

Scott Kelly, a NASA astronaut who took part in the most extensive study of the effects of long-term spaceflight after staying onboard the ISS for 340 days while his twin brother stayed back on Earth, lost 7% of his body mass while in orbit.

Eyesight

On Earth, gravity helps to force the blood in our bodies downward while the heart pumps it up again. In space, however, this process becomes messed up (although the body does adapt somewhat), and blood can accumulate in the head more than it normally would.

Some of this fluid can pool at the back of the eye and around the optic nerve, leading to oedema. This can lead to changes in vision such as decreased sharpness and structural changes in the eye itself. These changes can start to occur after just two weeks in space but as that time goes on, the risk increases. Some of the vision changes reverse within about a year of astronauts returning to Earth, but others can be permanent.

Exposure to galactic cosmic rays and energetic solar particles can also lead to other eye problems. The Earth’s atmosphere helps to protect us from these but once in orbit on the ISS, this protection disappears. While spacecraft can carry shielding to help keep out excess radiation, astronauts onboard the ISS have reported seeing flashes of light in their eyes as cosmic rays and solar particles hit their retina and optical nerves.

Neural shuffling

After his long stay on the ISS, however, Kelly’s cognitive performance was found to have changed little and had remained relatively the same as his brother’s on the ground. However, researchers did notice that the speed and accuracy of Kelly’s cognitive performance did decrease for around six months after he landed, possibly as his brain readjusted to the Earth’s gravity and his very different lifestyle back home.

A study on a Russian cosmonaut who spent 169 days on the ISS in 2014 also revealed some changes to the brain itself seem to occur while in orbit.

It found there were changes in the levels of neural connectivity in parts of the brain relating to motor function – in other words, movement – and also in the vestibular cortex, which plays an important role in orientation, balance and perception of our own motion.

This is perhaps unsurprising given the peculiar nature of weightlessness while in space; astronauts often have to learn how to move efficiently without gravity to anchor them to anything and adjust to a world where there is no up or down.

A more recent study has raised concerns about other changes in brain structure that can occur during long-term space missions. Cavities in the brain known as the right lateral and third ventricles (responsible for storing cerebrospinal fluid, providing nutrients to the brain and disposing of waste) can swell and take up to three years to shrink back to normal size.

Friendly bacteria

It is apparent from research in recent years that a significant key to good health is the make up and diversity of the microorgansims that live in and on our bodies. This microbiota can influence how we digest food, affect the levels of inflammation in our bodies and even alter the way our brains work.

Researchers examining Kelly after his trip to the ISS found that the bacteria and fungi living in his gut had altered profoundly compared to before he flew into space. This is perhaps not entirely surprising, given the very different food he was eating and the change in the people he spent his days with (we obtain a horrifying amount of gut and oral microorganisms from the people we live alongside).

But exposure to radiation and the use of recycled water, along with changes to his physical activity could all also have played a role.

Skin

Although there have now been five NASA astronauts who have spent more than 300 days in orbit, we have Kelly to thank again for insights into how his skin fared while in orbit. His skin was found to have heightened sensitivity and a rash for around six days after he returned from the space station. Researchers speculated that a lack of skin stimulation during the mission may have contributed to his skin complaint.

Genes

One of the most significant findings from Kelly’s prolonged journey into space was the effects it had on his DNA. At the end of each strand of DNA are structures known as telomeres, which are thought to help protect our genes from damage. As we age, these get shorter, but research on Kelly and other astronauts has revealed that space travel seems to alter the length of these telomeres.

“Most striking, however, was the finding of significantly longer telomeres during spaceflight,” says Susan Bailey, a professor of environmental and radiological health at Colorado State University who was part of the team studying Kelly and his brother.

She has done separate studies with another 10 unrelated astronauts who have taken part in shorter missions of around six months. “Also unexpected was that telomere length shortened rapidly on return to Earth for all crewmembers. Of particular relevance to long-term health and ageing trajectories, astronauts in general had many more short telomeres after spaceflight than they did before.”

Exactly why this happens is still being unravelled, she says. “We have some clues, but additional long-duration crewmembers – like Rubio, who spent one year in space – will be critical to really characterising and understanding this response and its potential health outcomes.”

One possible cause could be exposure to the complex mix of radiation while in space. Astronauts who experience long-term exposure while in orbit show signs of DNA damage, she says.

There were also some changes in gene expression – the mechanism that reads the DNA to produce proteins in cells – seen in Kelly that may have been related to his journey into space. Some of these related to the body’s response to DNA damage, bone formation and the immune system’s response to stress. Most of these changes, however, had returned to normal within six months of his return to Earth.

In June 2024, a new study highlighted some potential differences between the way the immune systems of male and female astronauts respond to spaceflight. Using gene expression data from samples obtained from the crew of the SpaceX Inspiration 4 mission, who spent just under three days in orbit in the autumn of 2021, it identified changes in 18 proteins related to the immune system, ageing and muscle growth.

Comparing their gene activity to those of 64 other astronauts on previous missions, the study found in the expression of three proteins that play a role in inflammation compared to before the flight. The men tended to be more sensitive to spaceflight, with more disruption to their gene activity and they took longer to return to a normal state after returning to Earth.

In particular, the researchers found the gene activity of two proteins known as interleukin-6, which helps to control levels of inflammation in the body, and interleukin-8, which is produced to gulde immune cells to sites of infection, were more effected in the men compared to the women. Another protein, called firbrinogen, which is involved in blood clotting, was also affected more in male astronauts.

But the researchers say they still need to unravel why women appear to be less sensitive to these particular effects of spaceflight, but it could be related to their response to stress.

You can hear NASA astronaut Peggy Whitson describe how her own time in space has changed her body in the video below. With an accumulated 675 days in space, she has spent more time in orbit than any other American, although the world record is currently held by Russian cosmonaut Oleg Kononenko, who has clocked up 878 days in space.

Immune system

Kelly received a series of vaccines before, during and after his trip into space and his immune system was found to react normally. But Bailey’s research has found that astronauts do suffer some decreases in white blood cell counts that fall in line with the doses of radiation they receive while in orbit.

There are still many questions to be answered, however, about what impact space travel can have on a bipedal, big-brained species that evolved to live on Earth. As researchers pour over Rubio’s medical tests, blood samples and scans following his 371 days in space, they will doubtless be hoping they will learn more.

Source: BBC