Propelled in part by the wildly contagious omicron variant, the U.S. death toll from COVID-19 hit 900,000 on Friday, less than two months after eclipsing 800,000.

The two-year total, as compiled by Johns Hopkins University, is greater than the population of Indianapolis, San Francisco, or Charlotte, North Carolina.

The milestone comes more than 13 months into a vaccination drive that has been beset by misinformation and political and legal strife, though the shots have proved safe and highly effective at preventing serious illness and death.

Just 64% of the population is fully vaccinated, or about 212 million Americans, according to the Centers for Disease Control and Prevention.

The latest 100,000 deaths encompass those caused by both the delta variant and omicron, which began spreading rapidly in December and became the predominant version in the U.S. before the month was out.

While omicron has proved less likely to cause severe illness than delta, the sheer number of people who became infected with it contributed to the high number of deaths.